A newly synthesized integral membrane protein destined for the plasma membrane would most likely pass through which of the following sequences of organelles?
Correct: C
Integral membrane proteins destined for the plasma membrane are synthesized on ribosomes attached to the Rough Endoplasmic Reticulum (RER). They are then inserted into the ER membrane. From the ER, they bud off in vesicles and travel to the Golgi apparatus for further processing, sorting, and packaging. Finally, they are transported via secretory vesicles that fuse with the plasma membrane, inserting the protein into the membrane. Lysosomes are involved in degradation, peroxisomes in metabolic reactions, and free ribosomes synthesize cytosolic or organellar proteins (like mitochondrial proteins), not integral membrane proteins for the plasma membrane.