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Problem 4 - Entrance Test

In CRISPR-Cas9 gene editing, which component is responsible for guiding the Cas9 endonuclease to the specific DNA target sequence?

Correct: A

The sgRNA hybridizes with the target DNA sequence and guides the Cas9 endonuclease to the specific genomic location. This allows precise DNA cleavage and editing. Other components like tracrRNA are part of the system but assist differently in the process.