Which of the following compounds will undergo Friedel-Crafts alkylation most readily with CH3Cl and AlCl3?
Correct: D
p-Fluoroanisole (C6H5OCH3 with -F) has the least deactivating group due to +R effect of -OCH3 and -I effect of -F being weaker than other halogens. Electron-rich aromatic rings undergo Friedel-Crafts more easily.